Original Research Paper Uses of Methotrexate in Ophthalmology: a Review

Methotrexate is a folic acid antagonist and immunosuppressive agent, which is being increasingly used in various ocular inammatory diseases. Its use in ophthalmology has been increasing in recent years because of its anti-inammatory activity and corticosteroid-sparing objective. It is currently used in recurrent anterior uveitis, intermediate uveitis, posterior or panuveitis, scleritis, peripheral ulcerative keratitis, necrotizing keratitis in rheumatoid arthritis, high-risk penetrating keratoplasty, etc. In addition to systemic administration of drug, intraocular administration of methotrexate can be a promising treatment option for uveitis. This article reviews the current trends and uses of methotrexate in ophthalmology and its related complications.